Formic Acid → 5-bromo-4-fluoro-1H-1,3-benzodiazole

HRID 475227Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 475227
[Br:1][C:2]1[C:3]([F:10])=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[OH-].[Na+].[CH:13](O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][CH:13]=[N:9][C:4]=2[C:3]=1[F:10]

Komponenten

4

Edukt 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 27832034-Bromo-3-fluorobenzene-1,2-diamine

Produkt 1

HCID 594744775-bromo-4-fluoro-1H-1,3-benzodiazoleAusbeute 92 %

Versuchsvorschrift

A mixture of 142 (25 g, 0.121 mol) and formic acid (75 mL) was heated to reflux for 1.5 h. After the completion of the reaction the reaction was cooled and made basic with 10% NaOH. The resulting solid was filtered and washed with water. Drying overnight under suction afforded 24 g (92%) of 5-bromo-4-fluoro-1H-benzoimidazole (144) as pale yellow solid which was used without further purification.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux for 1.5 h
  3. customAfter the completion of the reaction the reaction
  4. temperaturewas cooled
  5. filtrationThe resulting solid was filtered
  6. washwashed with water
  7. customDrying overnight under suction

Quellen und Nachweise

ORD-Eintrag
ord-f1583a4b3fe34a2290845f9da677cef6
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08637537B2

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