Pyridine → HCID 58713644, Verbindung

Reaktionsgleichung

[C:1]([O:5][C:6]([C:8]1[C:12]2[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[CH:15][C:11]=2[NH:10][N:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].N1C=CC=CC=1.[C:25]1([CH3:35])[CH:30]=[CH:29][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:27][CH:26]=1>C(Cl)Cl>[C:1]([O:5][C:6]([C:8]1[C:12]2[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[CH:15][C:11]=2[N:10]([S:31]([C:28]2[CH:29]=[CH:30][C:25]([CH3:35])=[CH:26][CH:27]=2)(=[O:33])=[O:32])[N:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

Versuchsvorschrift

To a solution of the pyrazole intermediate from step A (275 mg, 1.1 mmol) above in CH2Cl2 (5 mL) was added pyridine (178 μL, 2.2 mmol) and p-toluene sulfonyl chloride (230 mg, 1.21 mmol). After stirring the resulting reaction mixture at room temperature for 3 hours it was diluted with CH2Cl2, washed with 1N HCl, saturated NaHCO3, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography (SiO2) using 10% ethyl acetate-hexanes.