Hydrochloric Acid → HCID 178463090, Verbindung

HRID 47619

Reaktionsgleichung

Reaktionsgleichung von HRID 47619
[CH2:1]([N:3]1[C:7]([OH:8])=[CH:6][C:5]([CH3:9])=[N:4]1)[CH3:2].[OH-].[Ca+2].[OH-].[C:13](Cl)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.Cl>O1CCOCC1.O>[CH2:1]([N:3]1[C:7]([OH:8])=[C:6]([C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:20])[C:5]([CH3:9])=[N:4]1)[CH3:2]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 7412Benzoyl chlorideHCID 6093208Calcium HydroxideHCID 178463089HCID 178463089, Verbindung

Produkt 1

HCID 178463090HCID 178463090, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

A suspension of 1.4 g of 2-ethyl-5-methyl-2H-pyrazol-3-ol, 1.6 g of calcium hydroxide and 1.3 ml of benzoyl chloride in 70 ml of 1,4-dioxane was stirred at 110° C. for 3.5 h. 1 ml of water was added and the mixture was stirred at 110° C. for 2 h. 25 ml of 2N hydrochloric acid was added. The mixture was stirred at room temperature for 16 h and extracted three times with 60 ml of ethyl acetate. The combined extracts were dried over magnesium sulphate, filtered and evaporated to give 3.1 g of (1-ethyl-5-hydroxy-3-methyl-1H-pyrazol-4-yl)-phenyl-methanone as a yellow oil which was used without further purification. Mass spectrum (ES) m/z 231 [M+H]+, 272 [M+H+CH3CN]+.

Aufarbeitung

  1. stirringthe mixture was stirred at 110° C. for 2 h
  2. stirringThe mixture was stirred at room temperature for 16 h
  3. extractionextracted three times with 60 ml of ethyl acetate
  4. dry with materialThe combined extracts were dried over magnesium sulphate
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-511a9a50d53741a1922a723714862dbd
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699887B2

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