CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid
Reaktionsgleichung
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol is added 11.0 g of 5% Pd/C. The mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i. When hydrogen uptake ceases, the catalyst is filtered off, and the solvent is evaporated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which was used directly in the next step.
Aufarbeitung
- customis reduced at room temperature under a hydrogen
- filtrationWhen hydrogen uptake ceases, the catalyst is filtered off
- customthe solvent is evaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-180a29866e24432681a27dff44e17ebd
- Quelldatensatz
- uspto-grants-2004_03
- Patentnummer
- US06699894B1
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