Acetic Anhydride → Ethyl 2-[(2,2,3-trifluoro-1,4-benzodioxan-5-yl)methylene]-4-acetoxy-acetoacetate

HRID 476972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 476972
C(N=C[C:7]1([F:19])[C:12]([F:14])([F:13])[O:11][C:10]2[CH:15]=[CH:16][CH:17]=[CH:18][C:9]=2[O:8]1)CCC.[C:20]([O:23][CH2:24][C:25](=[O:32])[CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])(=[O:22])[CH3:21].[C:33](OC(=O)C)(=O)C>>[F:14][C:12]1([F:13])[O:11][C:10]2[CH:15]=[CH:16][CH:17]=[C:18]([CH:33]=[C:26]([C:25]([CH2:24][O:23][C:20](=[O:22])[CH3:21])=[O:32])[C:27]([O:29][CH2:30][CH3:31])=[O:28])[C:9]=2[O:8][CH:7]1[F:19]

Komponenten

4

Edukt 3

HCID 7918Acetic AnhydrideHCID 11480907Ethyl 4-acetoxyacetoacetateHCID 86743569Butyliminomethyl-2,2,3-trifluoro-1,4-benzodioxane

Produkt 1

HCID 53756174Ethyl 2-[(2,2,3-trifluoro-1,4-benzodioxan-5-yl)methylene]-4-acetoxy-acetoacetate

Versuchsvorschrift

50 mmol of 5-(butyliminomethyl-2,2,3-trifluoro-1,4-benzodioxane and 50 mmol of ethyl 4-acetoxy-acetoacetate are stirred in 80 ml of acetic anhydride for 24 hours. The mixture is hydrolyzed with about 1 l of ice-water and the oil which has separated out is separated off, taken up in methylene chloride, dried and used as the crude product.

Aufarbeitung

  1. customthe oil which has separated out
  2. customis separated off
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bdfc2d68bac94c4da429bbdc0aa2160f
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04886816

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