Water → HCID 19872277, Verbindung

HRID 477748Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 477748
[CH2:1]([S:8][C:9]1[N:13]=[C:12]([OH:14])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[B-](F)(F)F.[CH3:26][O+](C)C.O>ClCCl>[CH2:1]([S:8][C:9]1[N:13]=[C:12]([O:14][CH3:26])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 178518539HCID 178518539, Verbindung

Produkt 1

HCID 19872277HCID 19872277, VerbindungAusbeute 51,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-Benzylthio-5-hydroxy-1-phenyl-1,2,4-triazole (15 g) in dichloromethane (60 ml) was treated with trimethyloxonium tetrafluoroborate (15.7 g) and allowed to stand for 18 hours at room temperature. The reaction mixture was poured into water (200 ml) and the aqueous layer was washed with dichloromethane (2×100 ml). The dried organic layer was evaporated and then purified by column chromatography (silica/petroleum ether:ether), to give 8.1 g of the desired product.

Aufarbeitung

  1. washthe aqueous layer was washed with dichloromethane (2×100 ml)
  2. customThe dried organic layer was evaporated
  3. custompurified by column chromatography (silica/petroleum ether:ether)

Quellen und Nachweise

ORD-Eintrag
ord-0add69fccb2c4325b368ced7bf65ca27
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04889553

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