HCID 178419031, Verbindung → HCID 178418735, Verbindung

HRID 478185

Reaktionsgleichung

Reaktionsgleichung von HRID 478185
C([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1

Komponenten

4

Edukt 1

HCID 178419031HCID 178419031, Verbindung

Produkt 1

HCID 178418735HCID 178418735, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of N-(3-benzyloxy-phenyl)guanidine (5.0 g, 20.6 mmol) in EtOH (150 mL) was added palladium on carbon (10%, wet, 50% water, 0.5 g)). The mixture was stirred under hydrogen atmosphere overnight. The reaction was filtered through a plug of celite and the filtrate concentrated in vacuo. with toluene azeotroping to affored the desired material (2.83 g, 91%). 1H NMR (MeOH-d4) δ6.4-7 (m, 4H)

Aufarbeitung

  1. filtrationThe reaction was filtered through a plug of celite
  2. concentrationthe filtrate concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d6c02952b6ab4954bab6ec20e5471e3f
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642227B2

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