2H-pyran-3,5(4H,6H)-dione → methyl 4-(4-fluoro-3-iodophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

HRID 478299

Reaktionsgleichung

Reaktionsgleichung von HRID 478299
[O:1]1[CH2:6][C:5](=O)[CH2:4][C:3](=[O:8])[CH2:2]1.[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][C:11]=1[I:18].[NH2:19]/[C:20](/[CH3:26])=[CH:21]\[C:22]([O:24][CH3:25])=[O:23]>CO>[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]2[C:21]([C:22]([O:24][CH3:25])=[O:23])=[C:20]([CH3:26])[NH:19][C:5]3[CH2:6][O:1][CH2:2][C:3](=[O:8])[C:4]2=3)=[CH:12][C:11]=1[I:18]

Komponenten

5

Edukt 3

HCID 3252872H-pyran-3,5(4H,6H)-dioneHCID 643918Methyl 3-aminocrotonateHCID 103080734-Fluoro-3-iodobenzaldehyde

Produkt 1

HCID 18000962methyl 4-(4-fluoro-3-iodophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylateAusbeute 45,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The product from Example 11B (0.34 g, 3.0 mmol), the product from Example 30C (0.74 g, 3.0 mmol) and methyl 3-aminocrotonate (0.35 g, 3.0 mmol) in methanol (8 mL) were processed as described in Example 68A to provide the title compound (0.60 g).

Quellen und Nachweise

ORD-Eintrag
ord-30fc3e751320499c97cc9a2a6da98ec3
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642222B2

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