3-Bromo-4-fluorobenzaldehyde → 8-(3-Bromo-4-fluorophenyl)-11,11-dimethyl-5,12-dioxa-2-azatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10-dione

HRID 478311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 478311
[CH3:1][C:2]1([CH3:10])[C:7](=[O:8])[CH2:6][C:5](=O)[CH2:4][O:3]1.[Br:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[F:20])[CH:15]=O.[NH2:21]/[C:22](/[CH3:28])=[CH:23]\[C:24]([O:26]C)=[O:25]>C(O)C>[Br:11][C:12]1[CH:13]=[C:14]([CH:15]2[C:6]3[C:7](=[O:8])[C:2]([CH3:10])([CH3:1])[O:3][CH2:4][C:5]=3[NH:21][C:22]3[CH2:28][O:26][C:24](=[O:25])[C:23]2=3)[CH:17]=[CH:18][C:19]=1[F:20]

Komponenten

5

Edukt 3

HCID 1736043-Bromo-4-fluorobenzaldehydeHCID 643918Methyl 3-aminocrotonateHCID 140728872,2-dimethyl-2H-pyran-3,5(4H,6H)-dione

Produkt 1

HCID 102728278-(3-Bromo-4-fluorophenyl)-11,11-dimethyl-5,12-dioxa-2-azatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10-dioneAusbeute 21,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The product from Example 66C (0.50 g, 3.5 mmol), 3-bromo-4-fluorobenzaldehyde (0.88 g, 4.2 mmol) and methyl 3-aminocrotonate (0.40 g, 3.5 mmol) in ethanol (5 mL) were processed as described in Example 71 to provide the title compound (0.31 g).

Quellen und Nachweise

ORD-Eintrag
ord-092df8400ef7405e832621207cce1c70
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06642222B2

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