Water → Methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate

HRID 47928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47928
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=O)[O:11][C:12]=2[CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:22])=O.N1C=CC=CC=1.O>C(#N)C>[Cl:22][C:10]1[O:11][C:12]([CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=1

Komponenten

6

Edukt 4

HCID 962Water2×HCID 1049PyridineHCID 24813Phosphorus oxychlorideHCID 10956936Methyl 4-(4-chlorophenyl)-2-oxo-4-oxazoline-5-propionate

Produkt 1

HCID 10990225Methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionateAusbeute 91,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of methyl 4-(4-chlorophenyl)-2-oxo-4-oxazoline-5-propionate (823.7 g) and phosphorus oxychloride (1090 mL) was added pyridine (235.5 mL) and the mixture was stirred at 90° C. for 8 h and allowed to stand overnight at room temperature. A solution obtained by diluting the obtained mixture with acetonitrile (2471 mL) was added dropwise to water (8237 mL) at not higher than 35° C. Then water (4119 mL) was added and the precipitated crystals were collected by filtration to give the title compound (805.4 g, yield: 91.7%).

Aufarbeitung

  1. waitto stand overnight at room temperature
  2. customA solution obtained
  3. filtrationthe precipitated crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-e3a2be9bb64943668ba2349bcda48f0e
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699995B1

Notizen zur Reaktion

Wird geladen…