Ammonium Hydroxide → 2-Chloro-4-quinolineacetamide
Reaktionsgleichung
C[O:2][C:3](=O)[CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([Cl:15])[CH:6]=1.[NH4+:17].[OH-]>>[Cl:15][C:7]1[CH:6]=[C:5]([CH2:4][C:3]([NH2:17])=[O:2])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1Komponenten
3
Versuchsvorschrift
2-(2-chloro-quinolin-4-yl)-acetic acid methyl ester (100 mg, 0.42 mmol) is suspended in 28% NH4OH (2.0 mL). The mixture is stirred at RT overnight. The solvent is evaporated to afford 2-(2-chloro-quinolin-4-yl)-acetamide as a solid.
Aufarbeitung
- customThe solvent is evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-767f971628b647db9a1fb11dc623a007
- Quelldatensatz
- uspto-grants-2003_11
- Patentnummer
- US06645970B2
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