Potassium thiocyanate → 4-methyl-N-(2,2,2-trifluoro-1-isothiocyanatoethyl)benzamide

HRID 479472Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 479472
Cl[CH:2]([NH:7][C:8](=[O:16])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)[C:3]([F:6])([F:5])[F:4].[S-:17][C:18]#[N:19].[K+]>CC(C)=O>[CH3:15][C:12]1[CH:13]=[CH:14][C:9]([C:8]([NH:7][CH:2]([N:19]=[C:18]=[S:17])[C:3]([F:6])([F:5])[F:4])=[O:16])=[CH:10][CH:11]=1

Komponenten

4

Edukt 2

HCID 516872Potassium thiocyanateHCID 12150323N-(1-chloro-2,2,2-trifluoroethyl)-4-methylbenzamide

Produkt 1

HCID 121503244-methyl-N-(2,2,2-trifluoro-1-isothiocyanatoethyl)benzamideAusbeute 61,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A stirred solution of Example 1B (2.00 g, 8.00 mmol) in acetone (35 mL) at ambient temperature was treated with potassium thiocyanate (1.60 g, 16.0 mmol). The reaction mixture was stirred for 12 hours, concentrated, and the crude residue was purified by flash chromatography (elution with 40% ethyl acetate/hexanes) to provide 1.34 g of the desired product as an off-white solid.

Aufarbeitung

  1. concentrationconcentrated
  2. customthe crude residue was purified by flash chromatography (elution with 40% ethyl acetate/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-ae1143b2e1d6485fa6570a5ad5d8b773
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06645968B2

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