Thiophosgene → 2-Chloro-5-isothiocyanatopyridine
Reaktionsgleichung
[C:1](Cl)(Cl)=[S:2].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[N:10][CH:11]=1>C(Cl)(Cl)Cl>[Cl:12][C:9]1[CH:8]=[CH:7][C:6]([N:5]=[C:1]=[S:2])=[CH:11][N:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of thiophosgene (3.21 mL, 42.1 mmol) in chloroform (10 mL) was heated at reflux and treated with a solution of 5amino-2-chloropyridine (3.61 g, 28.1 mmol) in chloroform (25 mL) for 40 minutes. The solution was heated an additional 2 hours, the reaction mixture was cooled, and the solids formed were removed by filtration. Concentration of the filtrate provided 2.73 g of the desired product as a white solid.
Aufarbeitung
- temperatureat reflux
- temperatureThe solution was heated an additional 2 hours
- temperaturethe reaction mixture was cooled
- customthe solids formed
- customwere removed by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-76ceb25cf7374bbe9df1b49db161f721
- Quelldatensatz
- uspto-grants-2003_11
- Patentnummer
- US06645968B2
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