Hydrochloric Acid → 2-Amino-4-phenylamino-6-methylpyrimidine

HRID 480415

Reaktionsgleichung

Reaktionsgleichung von HRID 480415
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:8][C:9]1[N:14]=[C:13](Cl)[CH:12]=[C:11]([CH3:16])[N:10]=1.Cl.[OH-].[K+]>O>[C:2]1([NH:1][C:13]2[CH:12]=[C:11]([CH3:16])[N:10]=[C:9]([NH2:8])[N:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 14797Potassium HydroxideHCID 218102-Amino-4-chloro-6-methylpyrimidine

Produkt 1

HCID 6082032-Amino-4-phenylamino-6-methylpyrimidineAusbeute 34,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Compound No. 45. (CNI-4594) A mixture of aniline (0.93 g) and 2-amino-4-chloro-6-methylpyrimidine (1.44 g) in 36 mL water was treated with 0.84 mL conc HCl and heated at reflux for 1 hr. Addition of 20 mL 1N KOH gave a light buff solid, which was filtered out, dried, and recrystallized from ethyl acetate/2-methoxyethanol and ethyl acetate/hexane to give 0.69 g 4-phenylamino-2-amino-6-methylpyrimidine, mp 179-180° C.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 1 hr
  3. customgave a light buff solid, which
  4. filtrationwas filtered out
  5. customdried
  6. customrecrystallized from ethyl acetate/2-methoxyethanol and ethyl acetate/hexane

Quellen und Nachweise

ORD-Eintrag
ord-6b41bcf745214136b70b90502142cde3
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06649797B2

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