Morpholine → [2-methylsulfanyl-6-(morpholin-4-yl)-pyrimidin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine

HRID 480614

Reaktionsgleichung

Reaktionsgleichung von HRID 480614
Cl[C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]2[NH:12][N:13]=[C:14]([CH3:16])[CH:15]=2)[CH:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>>[CH3:9][S:8][C:6]1[N:5]=[C:4]([NH:10][C:11]2[NH:12][N:13]=[C:14]([CH3:16])[CH:15]=2)[CH:3]=[C:2]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[N:7]=1

Komponenten

3

Edukt 2

HCID 8083MorpholineHCID 178418729HCID 178418729, Verbindung

Produkt 1

HCID 178419055[2-methylsulfanyl-6-(morpholin-4-yl)-pyrimidin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine

Versuchsvorschrift

The above-prepared [6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine (2.42 g, 9.46 mmol) is heated in morpholine (10 mL) at 130° C. for 15 hours. The solvent is then removed in vacuo and the solid residue is triturated in EtOH and collected by filtration to give [2-methylsulfanyl-6-(morpholin-4-yl)-pyrimidin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine.

Aufarbeitung

  1. customThe solvent is then removed in vacuo
  2. customthe solid residue is triturated in EtOH
  3. filtrationcollected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-1d9a396bb9a04d7c96a5c1065a2accb9
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06653300B2

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