Uridine → 5'-O-(4-Methylbenzoyl)uridine

HRID 48089

Reaktionsgleichung

Reaktionsgleichung von HRID 48089
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[C@@H:11]1([N:20]2[CH:27]=[CH:26][C:24](=[O:25])[NH:23][C:21]2=[O:22])[O:19][C@H:16]([CH2:17][OH:18])[C@@H:14]([OH:15])[C@H:12]1[OH:13]>N1C=CC=CC=1>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:18][CH2:17][C@H:16]2[O:19][C@@H:11]([N:20]3[CH:27]=[CH:26][C:24](=[O:25])[NH:23][C:21]3=[O:22])[C@H:12]([OH:13])[C@@H:14]2[OH:15])=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6029UridineHCID 134054-Methylbenzoyl Chloride

Produkt 1

HCID 115885775'-O-(4-Methylbenzoyl)uridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

4-Methylbenzoyl chloride (10 mmol) is added to a solution of uridine (10 mmol) in 20 mL of pyridine. After no further progress occurs as observed by TLC, the volatile components are evaporated in vacuo. The residue is purified using flash chromatography to give the product as a colorless oil.

Aufarbeitung

  1. customthe volatile components are evaporated in vacuo
  2. customThe residue is purified

Quellen und Nachweise

ORD-Eintrag
ord-5fea9a53770246ee989f9ac9adc592d9
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06702705B1

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