Ethanol → 5-methyl-3H-benzofuran-2-one

HRID 481410

Reaktionsgleichung

Reaktionsgleichung von HRID 481410
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](=[O:11])[CH2:8][C:7]=2[CH:12]=1.C(O)C>C(O)C.C(OCC)(=O)C.[Pd]>[CH3:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](=[O:11])[CH2:8][C:7]=2[CH:12]=1

Komponenten

5

Edukt 2

HCID 702EthanolHCID 190662885-chloromethyl-3H-benzofuran-2-one2×

Produkt 1

HCID 100576465-methyl-3H-benzofuran-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 21584252Ethanol ethylacetateLösungsmittel

Versuchsvorschrift

A solution of the product of Step 1, above (55) (10.89 mmol), in ethanol/ethyl acetate (23 ml/5 ml) was added to 10 ml ethanol over 10% palladium catalyst on carbon (100 mg). The mixture was hydrogenated on a Parr shaker at 45 psi for 2 hours. The reaction mixture was filtered through celite and the organics were concentrated to dryness to obtain the title compound (56).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe organics were concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-bbbe0f91cc634aafa054f649f7c01920
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789415

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