Methyl iodide → 4-(1,1-Dimethyl-2-butynyl)anisole

To a stirred solution of Compound 53 (335 mg, 1.00 mmol) in THF (10 ml) was added n-BuLi (1.69M in hexane, 1.19 ml, 2.01 mmol) at -78° C. under N2, then warmed up to 0° C., and stirred for 1.5 h. MeI (213 mg, 1.50 mmol) was added, and stirred for 1.5 h at 0° C. The mixture was quenched by the addition of NH4Cl aq., and extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and concentrated. This was purified by SiO2 chromatography to give Compound 54 (162 mg, 86%) as a colorless oil.

1. stirringstirred for 1.5 h at 0° C
2. customThe mixture was quenched by the addition of NH4Cl aq.
3. extractionextracted with CH2Cl2
4. dry with materialThe combined organic layers were dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThis was purified by SiO2 chromatography

ORD-Eintrag

ord-2ea3746090b5481bb563e3337c69d2d3

Quelldatensatz

uspto-grants-1998_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05789423