Hydrochloric Acid → 2-Phenyl-3-pyridinol

HRID 481745

Reaktionsgleichung

Reaktionsgleichung von HRID 481745
Br[C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:9]1(B(O)O)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl>C1(C)C=CC=CC=1.C(O)C.[OH-].[Na+].O>[OH:8][C:7]1[C:2]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:3][CH:4]=[CH:5][CH:6]=1

Komponenten

8

Edukt 3

HCID 313Hydrochloric AcidHCID 230702-Bromo-3-pyridinolHCID 66827Phenylboronic Acid

Produkt 1

HCID 187052-Phenyl-3-pyridinolAusbeute 45,4 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 2-bromo-3-hydroxypyridine (2.20 g, 12.6 mmol), phenylboronic acid (2.00 g, 16.3 mmol) and palladium (tetrakis)triphenylphosphine (250 mg) in toluene (30 mL), ethanol (15 mL) and 5% aqueous sodium hydroxide (15 mL) was degassed with a stream of nitrogen and stirred vigorously at 100° C. overnight. The mixture was diluted with water (50 mL) and ethyl acetate (100 mL), and the organic layer was dried over sodium sulfate and concentrated, affording a yellow solid. This material was suspended in water (100 mL), a few mL of 1N HCl was added, and the resulting solution was extracted with ethyl acetate. The aqeuous layer was neutralized with saturated aqueous sodium bicarbonate, and again was extracted with ethyl acetate. The combined organic extracts were dried with sodium sulfate and concentrated to an oily solid, which was triturated with 2:1 hexane/ethylacetate, affording 0.98 g of 3-hydroxy-2-phenylpyridine.

Aufarbeitung

  1. customwas degassed with a stream of nitrogen
  2. additionThe mixture was diluted with water (50 mL) and ethyl acetate (100 mL)
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. concentrationconcentrated
  5. customaffording a yellow solid
  6. extractionthe resulting solution was extracted with ethyl acetate
  7. extractionagain was extracted with ethyl acetate
  8. dry with materialThe combined organic extracts were dried with sodium sulfate
  9. concentrationconcentrated to an oily solid, which
  10. customwas triturated with 2:1 hexane/ethylacetate

Quellen und Nachweise

ORD-Eintrag
ord-8a5361bd9518460199bb79193a1b9d7c
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789584

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