Water → HCID 19067073, Verbindung

HRID 481763Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 481763
I[CH:2]1[C:8](=[O:9])[NH:7][C:6]2[N:10]=[CH:11][CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1.[N-:14]=[N+:15]=[N-:16].[Na+].O.ClCCl>CN(C)C=O>[N:14]([CH:2]1[C:8](=[O:9])[NH:7][C:6]2[N:10]=[CH:11][CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1)=[N+:15]=[N-:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6344DichloromethaneHCID 33557Sodium AzideHCID 190670745,6,7,9-Tetrahydro-7-iodo-8H-pyrido[2,3-b]azepin-8-one

Produkt 1

HCID 19067073HCID 19067073, VerbindungAusbeute 94,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To 333 mg of the intermediate obtained in Step G in 6 mL of dimethylformamide (DMF) was added 600 mg of sodium azide. The mixture was stirred at 20° C. 20 h before addition of water and extraction with dichloromethane. The extracts were combined and dried over sodium sulfate. Evaporation of the solvent gave 223 mg of the product characterized by its NMR and mass spectra.

Aufarbeitung

  1. dry with materialdried over sodium sulfate
  2. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-9c8fea675a4c426d9124058290234526
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789587

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