2-(2-(Isopropyloxycarbonyl)ethyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline → 1,2,3,4-Tetrahydroisoquinoline

HRID 481787Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 481787
C(OC(CC[N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([N+]([O-])=O)=[CH:14][CH:15]=2)[CH2:10]1)=O)(C)C>CO.[C].[Pd]>[CH2:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17][CH2:18][NH:9]1

Komponenten

4

Edukt 1

HCID 190672012-(2-(Isopropyloxycarbonyl)ethyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline

Produkt 1

HCID 70461,2,3,4-TetrahydroisoquinolineAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The suspension (60 ml) in methanol of 1.58 g of 2-(2-(isopropyloxycarbonyl)ethyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline and 1.0 g of palladium-carbon (10%) was stirred for one day, and the catalyst was separated by filtration. The filtrate was concentrated under reduced pressure to obtain 1.11 g of 7-amino-2-(isopropyloxycarbonyl)ethyl)-1,2,3,4-tetrahydroisoquinoline (yield: 78%).

Aufarbeitung

  1. customthe catalyst was separated by filtration
  2. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7209348318af4b668c6a3d5c7fbc5910
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789595

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