Ethanol → N-(2-ethyl-1,2,3,4-tetrahydro-5-isoquinolinyl)acetamide

HRID 48201

Reaktionsgleichung

Reaktionsgleichung von HRID 48201
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-])=O.I[CH2:15][CH3:16].[CH3:17][CH2:18][OH:19]>>[CH2:15]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[CH:13][C:4]=2[NH:1][C:18](=[O:19])[CH3:17])[CH2:9]1)[CH3:16]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 6340IodoethaneHCID 690855-Nitroisoquinoline

Produkt 1

HCID 10398491N-(2-ethyl-1,2,3,4-tetrahydro-5-isoquinolinyl)acetamide

Versuchsvorschrift

A solution of 5-nitroisoquinoline (25 g, 0.144 mol) in 250 mL of EtOH was treated with iodoethane (26.9 g, 0.172 mol) and the resulting solution heated at reflux for 24 hours. The reaction mixture was cooled and the material which formed was collected and dried. The material obtained was converted to the title compound by the procedures described in Example 1. A white solid was obtained (4.42 g, 17%).

Aufarbeitung

  1. temperaturethe resulting solution heated
  2. temperatureat reflux for 24 hours
  3. temperatureThe reaction mixture was cooled
  4. customthe material which formed
  5. customwas collected
  6. customdried
  7. customThe material obtained

Quellen und Nachweise

ORD-Eintrag
ord-63374dd46e7b4aceb47f36df2ff1252c
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703391B2

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