8-Bromo-1,2,3,4-tetrahydro-6-nitro-2-propyl-5-isoquinolinamine → HCID 10058790, Verbindung

HRID 48206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 48206
Br[C:2]1[C:11]2[CH2:10][N:9]([CH2:12][CH2:13][CH3:14])[CH2:8][CH2:7][C:6]=2[C:5]([NH2:15])=[C:4]([N+:16]([O-])=O)[CH:3]=1>CO.[Pd]>[CH2:12]([N:9]1[CH2:8][CH2:7][C:6]2[C:11](=[CH:2][CH:3]=[C:4]([NH2:16])[C:5]=2[NH2:15])[CH2:10]1)[CH2:13][CH3:14]

Komponenten

4

Edukt 1

HCID 104257568-Bromo-1,2,3,4-tetrahydro-6-nitro-2-propyl-5-isoquinolinamine

Produkt 1

HCID 10058790HCID 10058790, VerbindungAusbeute 129,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of the product from Example 12 (1.50 g, 4.77 mmol) and 20% Pd on carbon (0.30 g) in 75 mL of MeOH was hydrogenated at room temperature and pressure for 24 hours. The reaction mixture was concentrated and the residue was suspended in iPr2O and collected by filtration to give the title compound as a yellow solid (1.27 g, 93%).

Aufarbeitung

  1. customwas hydrogenated at room temperature
  2. concentrationThe reaction mixture was concentrated
  3. filtrationcollected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-5ac0eb774d324534a4d251b21c2c0b90
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703391B2

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