Bromoacetyl chloride → N-[2-(2,6-Dimethoxy-4-methylbenzoyl)phenyl]-N-methylbromoacetamide

HRID 482466Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 482466
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][C:14]([CH3:19])=[CH:13][C:12]=1[O:20][CH3:21])=[O:10].[Br:22][CH2:23][C:24](Cl)=[O:25]>ClCCl.O>[CH3:21][O:20][C:12]1[CH:13]=[C:14]([CH3:19])[CH:15]=[C:16]([O:17][CH3:18])[C:11]=1[C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[N:2]([CH3:1])[C:24](=[O:25])[CH2:23][Br:22])=[O:10]

Komponenten

5

Edukt 2

HCID 89602Bromoacetyl chlorideHCID 57322216(2,6-Dimethoxy-4-methylphenyl)(2-methylaminophenyl) Ketone

Produkt 1

HCID 19062972N-[2-(2,6-Dimethoxy-4-methylbenzoyl)phenyl]-N-methylbromoacetamideAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

To a mixture of 10 g of (2,6-dimethoxy-4-methylphenyl) (2-methylaminophenyl) ketone in 100 ml of dichloromethane and 20 ml of water, cooled to -10° C., are added dropwise 6.34 g of bromoacetyl chloride in 20 dichloromethane. The reaction mixture is allowed to return to room temperature and is then stirred vigorously for 2 hours. The phases are separated after settling has taken place and the organic phase is successively washed with water, dried over sodium sulphate and evaporated to dryness to give beige crystals melting at 121° C.; Yield=99%.

Aufarbeitung

  1. customto return to room temperature
  2. customThe phases are separated after settling
  3. washthe organic phase is successively washed with water
  4. dry with materialdried over sodium sulphate
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-c793407ad3f74156a2da645ff92600ec
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05798353

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