Sodium borohydride → 3-(3,4-Dichlorophenyl)-4-hydroxy-1-methylimidazolidin-2-one

HRID 483050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 483050
[CH3:1][N:2]1[CH2:8][C:6](=[O:7])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[C:3]1=[O:4].[BH4-].[Na+]>CO>[CH3:1][N:2]1[CH2:8][CH:6]([OH:7])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[C:3]1=[O:4]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 130655013-(3,4-Dichlorophenyl)-1-methylimidazolidine-2,4-dione

Produkt 1

HCID 133423223-(3,4-Dichlorophenyl)-4-hydroxy-1-methylimidazolidin-2-oneAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

A 10.4 g (0.04 mole) quantity of 1-methyl-3-(3,4-dichlorophenyl)hydantoin was suspended in 80 ml of methanol. The suspension was cooled to 10° C. and 1.5 g of sodium borohydride was added thereto with stirring. After the addition, the mixture was stirred for 30 minutes and warmed to room temperature, followed by further agitation for 2 hours. After completion of the reaction, the reaction mixture was concentrated and water was added to the residue to deposit crystals. The crystals were filtered and recrystallized from ethanol, affording 9.2 g of white crystals in 88% yield.

Aufarbeitung

  1. additionAfter the addition
  2. stirringthe mixture was stirred for 30 minutes
  3. temperaturewarmed to room temperature
  4. customAfter completion of the reaction
  5. concentrationthe reaction mixture was concentrated
  6. additionwater was added to the residue to deposit crystals
  7. filtrationThe crystals were filtered
  8. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ee842a301c4c485abcff6b956cd87ed3
Quelldatensatz
uspto-grants-1986_03
Patentnummer
US04578107

Notizen zur Reaktion

Wird geladen…