Methyl 3-aminocrotonate → 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-chloro-3-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Beteiligte Stoffe

Reaktionsschritte

A mixture of 460 mg of 2-chloro-3-fluorobenzaldehyde, 360 mg of methyl 3-aminocrotonate and 820 mg of 2-(N-benzyl-N-methylamino)ethyl 3-aminocrotonate in 4 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to provide 860 mg of the desired compound (110).

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