反应详情

A mixture of 460 mg of 2-chloro-3-fluorobenzaldehyde, 360 mg of methyl 3-aminocrotonate and 820 mg of 2-(N-benzyl-N-methylamino)ethyl 3-aminocrotonate in 4 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to provide 860 mg of the desired compound (110).

1. temperaturewas refluxed for 8 hours
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue was purified by a column chromatography on silica gel