Isopropanol → HCID 70456982, Verbindung

HRID 483199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 483199
[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[NH2:13]/[C:14](/C)=[CH:15]\[C:16]([O:18][CH3:19])=[O:17].[C:21]([O:27][CH2:28][C:29]([CH3:41])([CH3:40])[CH2:30][N:31]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:32])(=[O:26])[CH2:22][C:23]([CH3:25])=O.[CH3:42]C(O)C>>[CH3:25][C:23]1([CH3:42])[CH:22]([C:21]([O:27][CH2:28][C:29]([CH3:41])([CH3:40])[CH2:30][N:31]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH3:32])=[O:26])[CH:5]([C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([Cl:1])[C:3]=2[N+:10]([O-:12])=[O:11])[C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][NH:13]1

Komponenten

5

Edukt 4

HCID 3776IsopropanolHCID 643918Methyl 3-aminocrotonateHCID 101083403-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetateHCID 122489723-CHLORO-2-NITROBENZALDEHYDE

Produkt 1

HCID 70456982HCID 70456982, Verbindung

Versuchsvorschrift

A mixture of 185 mg of 3-chloro-2-nitrobenzaldehyde, 118 mg of methyl 3-aminocrotonate and 292 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate in 1 ml of 2-propanol was refluxed for 12 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a method of column chromatography on silica gel to yield 337 mg of the desired compound (132).

Aufarbeitung

  1. temperaturewas refluxed for 12 hours
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was purified by a method of column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-7c373083ce3d4fbb96d390ffc50abd9a
Quelldatensatz
uspto-grants-1986_03
Patentnummer
US04578395

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