Oxalyl chloride → HCID 54425176, Verbindung

HRID 483311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 483311
[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3]([Cl:13])=[O:4]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 2568962-fluoro-3-methylpentanoic acid

Produkt 1

HCID 54425176HCID 54425176, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

Finally, to the compound (v) was added 10 ml of dichloromethane and then 15 ml of oxalic acid chloride dropwise with ice cooling. The reaction was carried out under reflux at 40° C. for 3 hours. The reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation, and the residues were purified by vacuum distillation. Thus there was obtained 2-fluoro-3-methylpentanoic acid chloride (vi), which has a boiling point of 58°-60° C. (at 20 mmHg).

Aufarbeitung

  1. distillationThe reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation
  2. distillationthe residues were purified by vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-da6bdb019bbd4e6081af3d78a728ff6c
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05225105

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