Hydrochloric Acid → HCID 10466579, Verbindung

HRID 483367

Reaktionsgleichung

Reaktionsgleichung von HRID 483367
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@@H:9]([C:11]([OH:13])=O)[NH2:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[O-:16][C:17]#[N:18].[K+].Cl>O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH:9]2[C:11](=[O:13])[NH:18][C:17](=[O:16])[NH:10]2)=[CH:14][CH:15]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 137064-Nitro-3-phenyl-L-alanineHCID 11378442Potassium cyanate

Produkt 1

HCID 10466579HCID 10466579, VerbindungAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A solution of p-nitrophenylalanine (4.2 g, Fluka) and potassium cyanate (1.62 g) in water (6 ml) was refluxed for 1 hour. C.HCl (3 ml) was added and the mixture refluxed for a further 10 minutes, then cooled, diluted with water and filtered. The residue was washed with water and dried to give the desired product as a straw-coloured solid (3.85 g). The 200 MHz 1H NMR was consistent with the proposed structure.

Aufarbeitung

  1. temperaturethe mixture refluxed for a further 10 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washThe residue was washed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-62efc28f41c543b7913ba1e431fd9ca5
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05225431

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