3,4-dihydro-2H-pyran → 2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-

HRID 483466

Reaktionsgleichung

Reaktionsgleichung von HRID 483466
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>Cl>[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:6]1[CH2:5][CH2:4][CH2:3][CH2:2][O:1]1

Komponenten

4

Edukt 2

HCID 80803,4-dihydro-2H-pyranHCID 135694-Chloro-1-butanol

Produkt 1

HCID 1704882H-Pyran, 2-(4-chlorobutoxy)tetrahydro-Ausbeute 89,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidKatalysator

Versuchsvorschrift

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1M, 50ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

Aufarbeitung

  1. washwashed with H2O (100 ml), aqueous NaHCO3 (1M, 50ml) and BR (50 ml)
  2. temperatureThe dried liquid was heated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2f1f6bb3aa0943b0855f794fab0230c3
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05225445

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