2-(Dimethylamino)ethanol → HCID 23176012, Verbindung

HRID 483477

Reaktionsgleichung

Reaktionsgleichung von HRID 483477
[CH3:1][N:2]1[CH2:12][CH2:11][CH2:10][CH2:9][CH:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:13][N:14](C)[CH2:15]CO.C([Sn](=O)CCCC)CCC>>[CH3:1][N:2]1[CH2:12][CH2:11][CH2:10][CH2:9][CH:3]1[C:4]([O:6][CH2:7][CH2:8][N:14]([CH3:15])[CH3:13])=[O:5]

Komponenten

4

Edukt 3

HCID 79022-(Dimethylamino)ethanolHCID 61221Dibutyltin oxideHCID 566742Ethyl 1-methylpiperidine-2-carboxylate

Produkt 1

HCID 23176012HCID 23176012, Verbindung

Reaktionsbedingungen

Temperatur
145 °C

Versuchsvorschrift

A mixture of 85 g (0.5 mol) of ethyl 1-methylpipecolinate, 44.6 g (0.5 mol) of N,N-dimethylethanolamine and 0.82 g of dibutyltin oxide was heated at about 145° C. for 30 hours. The ethanol by-product was collected in a Dean-Stark trap. When the rate of ethanol evolution and amount of ethanol collected showed that the reaction was essentially complete, the reaction was heated at about 180° C. until ethanol evolution ceased. The liquid product was purified by distillation at reduced pressure to provide 2-(N,N-dimethylamino)ethyl N-methylpipecolinate.

Aufarbeitung

  1. customThe ethanol by-product was collected in a Dean-Stark trap
  2. customWhen the rate of ethanol evolution and amount of ethanol collected
  3. temperaturethe reaction was heated at about 180° C. until ethanol evolution
  4. distillationThe liquid product was purified by distillation at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6e74ee1cb88d4903a3fa856dd9a5d693
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05225513

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