2-Chloro-4-nitropyridine 1-oxide → Pyridine, 2-chloro-4-methoxy-, 1-oxide

HRID 483758

Reaktionsgleichung

Reaktionsgleichung von HRID 483758
[Na].[CH3:2][O-:3].[Na+].[Cl:5][C:6]1[CH:11]=[C:10]([N+]([O-])=O)[CH:9]=[CH:8][N+:7]=1[O-:15]>CO>[Cl:5][C:6]1[CH:11]=[C:10]([O:3][CH3:2])[CH:9]=[CH:8][N+:7]=1[O-:15]

Komponenten

5

Edukt 3

HCID 844332-Chloro-4-nitropyridine 1-oxideHCID 5360545SodiumHCID 10942334Sodium Methoxide

Produkt 1

HCID 15593755Pyridine, 2-chloro-4-methoxy-, 1-oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

Sodium (0.46 g) is dissolved in absolute methanol (50 ml) and the resultant solution of sodium methoxide is added to a solution of 2-chloro-4-nitropyridine-1-oxide (3.5 g, prepared as described in Example 1) in methanol (10 ml). The reaction mixture is allowed to stand at room temperature for 50 hours and is then subjected to rotary evaporation to give 2-chloro-4-methoxypyridine-1-oxide.

Aufarbeitung

  1. customis then subjected to rotary evaporation

Quellen und Nachweise

ORD-Eintrag
ord-20eeab3c45f14020a6979e4c216e0572
Quelldatensatz
uspto-grants-1993_07
Patentnummer
USRE034313

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