Hydrochloric Acid → HCID 5744998, Verbindung

Norpethidine (15.63 g, 67 mmol), 4-ethoxybutylchloride (10.67 g, 70 mmol), Na2CO3 (7.77 g, 73 mmol), KI (0.6 g) and acetonitrile (150 ml) were heated under reflux and stirring for 72 h. The mixture was filtered and the solvent removed. The residue was dissolved in diethyl ether, and the solution washed with water and dried (MgSO4). Destillation yielded 17.9 g of base boiling at 160°-163° C./0.05 mm Hg. B.p. acc. to J. Chem. Soc. 3062 (1958) 180° C./1 mm Hg. Hydrochloride m.p. 143°-145° C.

1. temperatureunder reflux
2. filtrationThe mixture was filtered
3. customthe solvent removed
4. dissolutionThe residue was dissolved in diethyl ether
5. washthe solution washed with water
6. dry with materialdried (MgSO4)
7. customDestillation yielded 17.9 g of base boiling at 160°-163° C./0.05 mm Hg
8. custom3062 (1958) 180° C./1 mm Hg

ORD-Eintrag

ord-f9d1676c42964943926696a83eab1022

Quelldatensatz

uspto-grants-1993_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05227389