(Phenylmethoxy)-n-[2-(5-{2-[(phenylmethoxy)carbonylamino]ethyl}(2-thienyl))ethyl]carboxamide → 2-[5-(2-Aminoethyl)-2-thienyl]ethylamine
Reaktionsgleichung
C1(COC([NH:11][CH2:12][CH2:13][C:14]2[S:15][C:16]([CH2:19][CH2:20][NH:21]C(OCC3C=CC=CC=3)=O)=[CH:17][CH:18]=2)=O)C=CC=CC=1>[Pd]>[NH2:11][CH2:12][CH2:13][C:14]1[S:15][C:16]([CH2:19][CH2:20][NH2:21])=[CH:17][CH:18]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
(Phenylmethoxy)N-[2-(5-{2-[(phenylmethoxy)carbonylamino]ethyl}(2-thienyl))ethyl]carboxamide (1.6 g, 3.6 mmol) and 10% palladium on carbon (1.0 g, 62 mole %) were combined and hydrogenation was carried out in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, 2-[5-(2-aminoethyl)-2-thienyl]ethylamine, (0.935 g, 55%) as a colorless oil.