1,3,4,9-Tetrahydro-1,1-diethyl-6-(phenylmethoxy)pyrano[3,4-b]indole → HCID 19935698, Verbindung

HRID 484255

Reaktionsgleichung

Reaktionsgleichung von HRID 484255
[CH2:1]([C:3]1([CH2:24][CH3:25])[C:8]2[NH:9][C:10]3[C:15]([C:7]=2[CH2:6][CH2:5][O:4]1)=[CH:14][C:13]([O:16]CC1C=CC=CC=1)=[CH:12][CH:11]=3)[CH3:2]>[Pd].C(O)C>[CH2:24]([C:3]1([CH2:1][CH3:2])[C:8]2[NH:9][C:10]3[C:15]([C:7]=2[CH2:6][CH2:5][O:4]1)=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=3)[CH3:25]

Komponenten

4

Edukt 1

HCID 199357021,3,4,9-Tetrahydro-1,1-diethyl-6-(phenylmethoxy)pyrano[3,4-b]indole

Produkt 1

HCID 19935698HCID 19935698, VerbindungAusbeute 109,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture consisting of 10% Pd/c on charcoal (1.0 g), ethanol (125 mL), and 1,3,4,9-tetrahydro-1,1-diethyl-6-(phenylmethoxy)pyrano[3,4-b]indole (6.5 g, 0.0193 mol), of Step A, is hydrogenated at 30 psi for 18 hours. The reaction mixture is filtered and concentrated to give 5.2 g of product which is used in the next reaction without further purification.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9bd569f7b3ff4c85be7cc8ea789a80b4
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05229516

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