Water → 2-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-ol

A solution of (2,3-dihydrobenzofuran-5-yl) acetic acid (4.9 g--see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 10 minutes to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0° C. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was cautiously added dropwise followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2×50 ml). The filtrate and washings were combined and concentrated in vacuo to give the title compound as an oil, (3.3 g).

1. filtrationThe mixture was filtered
2. washthe inorganic salts washed with ethyl acetate (2×50 ml)
3. concentrationconcentrated in vacuo

ORD-Eintrag

ord-08ba30a820e94f7898d62aca50241d86

Quelldatensatz

uspto-grants-1993_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05231104