1,4-Dioxane hydrochloride → 2-Amino-4-methoxycarbonylindan hydrochloride

HRID 48438Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 48438
C(OC([NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][C:15]=2[C:18]([O:20][CH3:21])=[O:19])[CH2:10]1)=O)(C)(C)C.[ClH:22].O1CCOCC1>C(O)(=O)C>[ClH:22].[NH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][C:15]=2[C:18]([O:20][CH3:21])=[O:19])[CH2:10]1

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22719600HCID 22719600, Verbindung

Produkt 1

HCID 227196362-Amino-4-methoxycarbonylindan hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Using 2-(tert-butoxycarbonylamino)-4-methoxycarbonylindan (45 mg, 0.15 mmol) synthesized in the above Reference Production Example 7, 4N hydrochloric acid-dioxane (0.7 ml) and acetic acid (2.1 ml), a similar procedure to Production Example 213 was carried out to obtain 2-amino-4-methoxycarbonylindan hydrochloride. Then, using the 2-amino-4-methoxycarbonylindan hydrochloride, 4-chloro-5-methylthieno[2,3-d]pyrimidine (28 mg, 0.15 mmol), triethylamine (63 μl, 0.45 mmol), and ethanol (1 ml), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (15 mg, 0.044 mmol) having the following physical properties:

Quellen und Nachweise

ORD-Eintrag
ord-fdc65dc949f54155be641d22de6225c0
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703421B1

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