Formamide → HCID 178518030, Verbindung
Reaktionsgleichung
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[NH2:10])=O.[CH:11]([NH2:13])=O>O>[OH:2][C:3]1[C:5]2[S:6][CH:7]=[CH:8][C:9]=2[N:10]=[CH:11][N:13]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 200 °C
Versuchsvorschrift
3-aminothiophene-2-carboxylic acid methylester (1.6 g, 10 mmol) was added to formamide (3.4 ml), and the mixture was stirred at 200° C. for 2 hours. The reaction mixture was returned to room temperature, and water was added thereto, which was extracted with chloroform. The solid obtained by distilling off the solvent under reduced pressure was washed with ethyl acetate to obtain 4-hydroxythieno[3,2-d]pyrimidine (60 mg, 0.39 mmol).
Aufarbeitung
- customwas returned to room temperature
- extractionwhich was extracted with chloroform
- customThe solid obtained
- distillationby distilling off the solvent under reduced pressure
- washwas washed with ethyl acetate
Quellen und Nachweise
- ORD-Eintrag
- ord-acd8ccb1d4e34ab0a44c61593a48bc0e
- Quelldatensatz
- uspto-grants-2004_03
- Patentnummer
- US06703421B1
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