Formamide → HCID 178518030, Verbindung

HRID 48447

Reaktionsgleichung

Reaktionsgleichung von HRID 48447
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[NH2:10])=O.[CH:11]([NH2:13])=O>O>[OH:2][C:3]1[C:5]2[S:6][CH:7]=[CH:8][C:9]=2[N:10]=[CH:11][N:13]=1

Komponenten

4

Edukt 2

HCID 713FormamideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

Produkt 1

HCID 178518030HCID 178518030, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

3-aminothiophene-2-carboxylic acid methylester (1.6 g, 10 mmol) was added to formamide (3.4 ml), and the mixture was stirred at 200° C. for 2 hours. The reaction mixture was returned to room temperature, and water was added thereto, which was extracted with chloroform. The solid obtained by distilling off the solvent under reduced pressure was washed with ethyl acetate to obtain 4-hydroxythieno[3,2-d]pyrimidine (60 mg, 0.39 mmol).

Aufarbeitung

  1. customwas returned to room temperature
  2. extractionwhich was extracted with chloroform
  3. customThe solid obtained
  4. distillationby distilling off the solvent under reduced pressure
  5. washwas washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-acd8ccb1d4e34ab0a44c61593a48bc0e
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703421B1

Verknüpfte Notizen

Wird geladen…