1-Chloromethylnaphthalene → Terbinafine Hydrochloride

To a solution of 1.77 g (10 mmol) of 1-chloromethylnaphthalene in 10 ml of dimethyl sulfoxide were added 1.88 g (10 mmol) of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)methylamine hydrochloride and 1.66 g (12 mmol) of potassium carbonate under ice cooling. The mixture was stirred for 16 hours at room temperature, poured into 200 ml of ethyl acetate, washed with 100 ml×2 of water, a mixture of 80 ml of water and 10 ml of 2N hydrochloric acid, and 50 ml of saturated sodium chloride aqueous solution respectively, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to crystallize. The crystals were suspended in 10 ml of ethyl acetate, cooled, filtered and dried under reduced pressure to obtain 2.95 g (yield: 90%) of the above identified compound as off-white crystalline powder.

1. washwashed with 100 ml×2 of water
2. additiona mixture of 80 ml of water and 10 ml of 2N hydrochloric acid, and 50 ml of saturated sodium chloride aqueous solution respectively
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customto crystallize
6. temperaturecooled
7. filtrationfiltered
8. customdried under reduced pressure
9. customto obtain 2.95 g (yield: 90%) of the

ORD-Eintrag

ord-c2af800ea04c4ab5bb6389acc014116e

Quelldatensatz

uspto-grants-1993_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05231183