Terbinafine Hydrochloride

HCID 5282481CAS 78628-80-5
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Grundinformationen

Standard-SMILES
CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12.Cl
InChIKey
BWMISRWJRUSYEX-SZKNIZGXSA-N
Summenformel
C21H26ClN
Durchschnittliche Molmasse
327,9 g/mol
Monoisotopische Masse
327,1753775

Namen und Bezeichner

Bevorzugter Name
Terbinafine Hydrochloride
IUPAC
(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine;hydrochloride
Englischer Name
Terbinafine Hydrochloride
Summenformel
C21H26ClN
Molmasse
327.89

Namen und Synonyme

Terbinafine hydrochloride78628-80-5Terbinafine HClLamisil ATBramazilBramizilMuzonalTerbinaTerbineNSC-759113Terbinafine (as hydrochloride)012C11ZU6G
Weitere Namen anzeigen
LAMISILlamosilDacronin hydrochlorideTerbisilmethylamin hclAfoganD02219Brican
(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine hydrochlorideCHEBI:77614DTXSID90229223(2E)-N,6,6-TRIMETHYL-N-(NAPHTHALEN-1-YLMETHYL)HEPT-2-EN-4-YN-1-AMINE HYDROCHLORIDEShopriteCuristSilkaLamisil once

Datenbank-Bezeichner

CAS
78628-80-5
PubChem CID
5282481
DTXSID
DTXSID90229223
ChEMBL
CHEMBL1200832
ChEBI
CHEBI:77614
UNII
012C11ZU6G
EC Number
616-640-4、691-642-6

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
3,2 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
5
Schwere Atome
23

Experimentelle und physikochemische Eigenschaften

Collision Cross Section185.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt
204 · 204-208°C
storage temp.
15 · 15-25°C
Löslichkeit
50 mg/mL · methanol: soluble50mg/mL
Aggregatzustand
powder
Farbe
white
Merck
14 · 14,9156

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 0.6% (1 of 179) of reports.

Warning

H315 (46.4%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (46.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (46.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H400 (87.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (95.5%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 179 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 179 reports by companies.；There are 21 notifications provided by 178 of 179 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 13-08-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/12149

Terbinafine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesSkin Irrit. 2 (46.4%)；Eye Irrit. 2 (46.4%)；STOT SE 3 (46.4%)；Aquatic Acute 1 (87.2%)；Aquatic Chronic 1 (95.5%)

Toxikologische Informationen

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Terbinafine hydrochloride

vMost-DILI-concern

8

Warnings & precautions

DOI:10.1016/j.drudis.2016.02.015

Regulatorische Informationen

Regulatory Information · 2 Einträge

Status: Active Update: 13-08-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/12149

Terbinafine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Sicherheitsdaten

wgk
3
ridadr
UN 3077 9/PG 3
hs_code
29214990
RTECS-Nr.
QJ8600100
risk_code
36/37/38-50/53
Toxizität
LD50 in mice, rats (mg/kg): 4000, 4000 orally; 393, 213 i.v. (Ganzinger)

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 4 Einträge

TERBINAFINE HYDROCHLORIDE

Allylamine [CS]; Allylamine Antifungal [EPC]

TERBINAFINE TABLETS 250 MG

Allylamine Antifungal [EPC]; Allylamine [CS]

MeSH Pharmacological Classification · 2 Einträge

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Anwendungen · 1 Eintrag

BeschreibungTerbinafine hydrochloride is the first orally active allylamine antifungal with 30-fold greater antifungal activity than naftifine. The compound is indicated for the treatment of ringworm and fungal nail infections. Terbinatine hydrochloride acts on a single fungal enzyme, squalene epoxidase, interfering with the biosynthesis of ergosterols in cell membranes. Unlike other antifungal agents, it does not inhibit cytochrome P450 enzymes.

Vor- und nachgelagerte Produkte

Nachgelagerte Produkte

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
济南诚汇双达生物有限公司053158897070 15550412551

Ergänzende Hinweise

DefinitionChEBI: A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride.

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