Hydrochloric Acid → 2-[(2-Methyl-4-aminophenyl)amino]-1-pyrroline, dihydrochloride

HRID 484786

Reaktionsgleichung

Reaktionsgleichung von HRID 484786
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH2:16][CH2:15][CH2:14][N:13]=1.[ClH:17]>C(O)C.[Pd]>[ClH:17].[ClH:17].[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH2:16][CH2:15][CH2:14][N:13]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 13520142N-(2-Methyl-4-nitrophenyl)-3,4-dihydro-2H-pyrrol-5-amine

Produkt 1

HCID 1317142942-[(2-Methyl-4-aminophenyl)amino]-1-pyrroline, dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The product compound of Example 8 was dissolved in 1.2 liter of ethanol containing 53.4 ml of concentrated hydrochloric acid and hydrogenated at 2 psi over 5% palladium on carbon. After removal of catalyst by filtration, the filtrate was concentrated in vacuo to give 85 g of the title compound. Structure assignment was supported by the nmr spectrum and by elemental analysis.

Aufarbeitung

  1. customAfter removal of catalyst
  2. filtrationby filtration
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7b907801ad1e442e9344b86ae0bea55e
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04533739

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