Phosgene → 2,3-Dihydro-1H-pyrrolizine-5-carbonyl chloride

HRID 485367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 485367
[C:1]([Cl:4])(Cl)=[O:2].[CH2:5]1[C:12]2[N:8]([CH:9]=[CH:10][CH:11]=2)[CH2:7][CH2:6]1>C1(C)C=CC=CC=1.CCOCC>[CH2:11]1[C:12]2[N:8]([C:7]([C:1]([Cl:4])=[O:2])=[CH:6][CH:5]=2)[CH2:9][CH2:10]1

Komponenten

5

Edukt 2

HCID 6371PhosgeneHCID 2593612,3-Dihydro-1H-pyrrolizine

Produkt 1

HCID 134904052,3-Dihydro-1H-pyrrolizine-5-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a stirred, ice-bath cooled portion (30 ml) of 12.5% phosgene in toluene was added a solution of 2,3-dihydro-1H-pyrrolizine (0.80 g, 0.0074 m) in ether (30 ml) dropwise over ca two minutes. After stirring cold for ca 2.5 hr, the reaction mixture is allowed to warm to room temperature, the volatiles are removed in vacuo, and the resultant crystalline 2,3-dihydro-1H-pyrrolizine-5-carbonyl chloride used as is in the next step.

Aufarbeitung

  1. customthe volatiles are removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c810a1ac01334986988088ce79433d35
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04536512

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