Methanol → HCID 20270357, Verbindung

HRID 485369Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 485369
[CH2:1]1[C:8]2[N:4]([C:5]([C:9]([C:11]3[N:12]4[C:16](=[C:17]([C:20]([O:22]CC)=[O:21])[C:18]=3[CH3:19])[CH:15]([C:25]([O:27]CC)=[O:26])[CH2:14][CH2:13]4)=[O:10])=[CH:6][CH:7]=2)[CH2:3][CH2:2]1.CO.[OH-].[K+]>O>[CH2:1]1[C:8]2[N:4]([C:5]([C:9]([C:11]3[N:12]4[C:16](=[C:17]([C:20]([OH:22])=[O:21])[C:18]=3[CH3:19])[CH:15]([C:25]([OH:27])=[O:26])[CH2:14][CH2:13]4)=[O:10])=[CH:6][CH:7]=2)[CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 13490406HCID 13490406, Verbindung

Produkt 1

HCID 20270357HCID 20270357, VerbindungAusbeute 100,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A mixture of the diester from Step B (1.62 g, 0.004 m), methanol (15 ml), water (5 ml), and potassium hydroxide (1.6 g, 0.026 m) was refluxed in an inert atmosphere for 5.5 hours, cooled, diluted with water (ca. 80 ml), filtered, the filtrate acidified with 2N hydrochloric acid, and the cooled, aged mixture filtered. After drying the well-washed (water) solid, 1.4 g of 5-(2,3-dihydro-1H-pyrrolizin-5-oyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1,7-dicarboxylic acid is obtained as a white solid.

Aufarbeitung

  1. temperaturewas refluxed in an inert atmosphere for 5.5 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. filtrationfiltered
  5. customAfter drying the
  6. washwell-washed (water) solid

Quellen und Nachweise

ORD-Eintrag
ord-34cbce52408c41a68ff9b5b46897831b
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04536512

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