Formaldehyde → 4-[3-(1-Piperidinylmethyl)phenoxy]butanal

HRID 485376

Reaktionsgleichung

Reaktionsgleichung von HRID 485376
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[O:11][CH2:12][CH2:13][CH2:14][CH:15]=NNC(N)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C=O.C(=O)([O-])[O-:27].[Na+].[Na+]>Cl.O>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[O:11][CH2:12][CH2:13][CH2:14][CH:15]=[O:27])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

6

Edukt 3

HCID 712FormaldehydeHCID 10340Sodium CarbonateHCID 540828474-[3-(1-Piperidinylmethyl)phenoxy]butanal semicarbazone

Produkt 1

HCID 212975474-[3-(1-Piperidinylmethyl)phenoxy]butanal

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

4-[3-(1-piperidinylmethyl)phenoxy]butanal semicarbazone (9.43 g) and 37% formaldehyde (80 ml) in 2N hydrochloric acid (80 ml) were stirred at room temperature for 2.5 h and then diluted with water. The solution was basified with sodium carbonate and extracted with ether. The organic extract was washed with brine, and distilled to give the title compound as a colourless oil (5.59 g) b.p. 200°, 0.06 mm; tlc methanol Rf 0.7.

Aufarbeitung

  1. extractionextracted with ether
  2. extractionThe organic extract
  3. washwas washed with brine
  4. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-838e4ec62b9849b5a1de5c6fa6cb6f77
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04536508

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