Hydrochloric Acid → 2-Ethyl-[1,1'-biphenyl]-3-carboxylic acid

HRID 485552Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 485552
[CH2:1]([C:3]1[C:8]([C:9](N)=[O:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2].[OH-:18].[K+].Cl>OCCOCCO.C(OCC)C>[CH2:1]([C:3]1[C:8]([C:9]([OH:18])=[O:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 202706622-Ethyl[1,1'-biphenyl]-3-carboxamide

Produkt 1

HCID 202706372-Ethyl-[1,1'-biphenyl]-3-carboxylic acidAusbeute 104,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8117Diethylene GlycolLösungsmittel

Versuchsvorschrift

A stirred solution of 2-ethyl-[1,1'-biphenyl]-3-carboxamide (2.1 g, 0.0093 mole) and potassium hydroxide (26.3 g, 0.4 mole) in 175 ml of 2-hydroxyethyl ether was heated at 163° for approximately 18 hours. The reaction mixture was cooled and diluted with 150 ml of ice water. The solution was acidified with concentrated hydrochloric acid to form a precipitate. The precipitate was isolated by filtration and dissolved in diethyl ether; the ethereal solution was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated to give 2-ethyl-[1,1'-biphenyl]-3-carboxylic acid (2.2 g) as a solid.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customto form a precipitate
  3. customThe precipitate was isolated by filtration
  4. dry with materialthe ethereal solution was dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-0372c45023f548a19cc69eb3a022baec
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04536591

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