Hydrochloric Acid → 4-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine

HRID 485810Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 485810
[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)[CH3:2].Cl>C(O)C.O.[Pt]=O>[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1)[CH3:2]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 137267364-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine

Produkt 1

HCID 134731494-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidineAusbeute 70,6 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

The solution of 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine (1.1 g, 0.0054M) in ethanol (15 ml) and water (15 ml) was added con.HCl (3 ml) and platinum oxide (0.2 g). The mixture was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness in vacuo. The residue was dissolved in methanol (25 ml) and sodium methoxide (0.011M) was added and filtered. The filtrate was stripped to dryness and distilled at about 150° to about 175° C./0.2 mmHg to yield 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine as an oil (0.8 g, 70% yield).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. dissolutionThe residue was dissolved in methanol (25 ml)
  3. additionsodium methoxide (0.011M) was added
  4. filtrationfiltered
  5. distillationdistilled at about 150° to about 175° C./0.2 mmHg

Quellen und Nachweise

ORD-Eintrag
ord-efecbbf621ea4214b69b702105bf4d5d
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04537969

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