Water → HCID 178441853, Verbindung

HRID 486621Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 486621
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10](I)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Cu][C:18]#[N:19].O>N1C=CC=CC=1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 3

HCID 962WaterHCID 178418546HCID 178418546, VerbindungHCID 178441862HCID 178441862, Verbindung

Produkt 1

HCID 178441853HCID 178441853, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of 6.4 g of 2-butyl-6-iodo-4(1H)-quinazolinone in 25 ml of pyridine is added 3.6 g of copper(I) cyanide followed by heating at reflux for 16 hours. The reaction mixture is poured into water and stirred at room temperature for 8 hours. The suspension is filtered and the cake washed well with water and air dried. The solid is dissolved in 3:1 chloroform-methanol and dried with MgSO4. The volatiles are evaporated in vacuo to give 3.2 g of the desired pro-duct as a solid. m.p. 243°-45° C.

Aufarbeitung

  1. temperatureby heating
  2. temperatureat reflux for 16 hours
  3. filtrationThe suspension is filtered
  4. washthe cake washed well with water and air
  5. customdried
  6. dissolutionThe solid is dissolved in 3:1 chloroform-methanol
  7. dry with materialdried with MgSO4
  8. customThe volatiles are evaporated in vacuo
  9. customto give 3.2 g of the

Quellen und Nachweise

ORD-Eintrag
ord-79fc4ab865b54047a5aa4e1557c3feda
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05292742

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