Acetic Anhydride → HCID 19095933, Verbindung

HRID 486779Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 486779
[OH:1][C:2]1[C:7]2=[CH:8][C:9]3[C:14]([N:6]2[CH2:5][CH:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:3]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:13][CH:12]=[CH:11][CH:10]=3.[C:25](OC(=O)C)(=[O:27])[CH3:26]>N1C=CC=CC=1>[C:25]([O:1][C:2]1[C:7]2=[CH:8][C:9]3[C:14]([N:6]2[CH2:5][CH:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:3]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:13][CH:12]=[CH:11][CH:10]=3)(=[O:27])[CH3:26]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 54684685HCID 54684685, Verbindung

Produkt 1

HCID 19095933HCID 19095933, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

From a mixture of 29.3 g of diethyl 6,7-dihydro-9-hydroxypyrido[1,2-a]indole-7,8-dicarboxylate, 100 ml of pyridine and 30 ml of acetic anhydride, the solvents were removed under reduced pressure and the residue was partitioned between ethyl acetate and 2M hydrochloric acid. The organic extract was washed with saturated sodium bicarbonate solution and water, dried and evaporated to give 33 g of diethyl 9-acetoxy-6,7-dihydropyrido[1,2-a]indole-7,8-dicarboxylate.

Aufarbeitung

  1. customthe solvents were removed under reduced pressure
  2. customthe residue was partitioned between ethyl acetate and 2M hydrochloric acid
  3. extractionThe organic extract
  4. washwas washed with saturated sodium bicarbonate solution and water
  5. customdried
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f40ad0f0844745faa02dbe3e7719ce53
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05292747

Notizen zur Reaktion

Wird geladen…