Morpholine → 2-(Morpholin-4-yl)pyridine-4-carbonitrile

HRID 487309Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487309
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>>[N:10]1([C:2]2[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=2)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

Komponenten

3

Edukt 2

HCID 8083MorpholineHCID 5686382-Chloro-4-cyanopyridine

Produkt 1

HCID 146408562-(Morpholin-4-yl)pyridine-4-carbonitrileAusbeute 53 %

Versuchsvorschrift

A mixture of 2-chloro-4-cyanopyridine (2.5 g, 18 mmol) and morpholine (6.29 g, 72 mmol) was heated at 110°-120° C. for 4 hours. The reaction mixture was cooled, poured into ice-water (15 ml) and stirred for 30 minutes. A yellow solid was obtained, which was collected by filtration, washed with water and dried in vacuo at 70° C. in the presence of P2O5 to afford 1.8 g (53%) of 2-(4-morpholinyl)-4-cyanopyridine, m.p. 135°-136.5° C.

Aufarbeitung

  1. temperaturewas heated at 110°-120° C. for 4 hours
  2. temperatureThe reaction mixture was cooled
  3. customA yellow solid was obtained
  4. filtrationwhich was collected by filtration
  5. washwashed with water
  6. dry with materialdried in vacuo at 70° C. in the presence of P2O5

Quellen und Nachweise

ORD-Eintrag
ord-7f8515f161a242308b6a73b72b753a00
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05294612

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